Document Type
Article
Abstract
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
Publication Date
October 2014
Publication Title
PLoS ONE
Volume
9
Issue
10
First Page
1
Last Page
10
DOI
10.1371/journal.pone.0109361
Recommended Citation
Rath, Nigam; Sharma, Vijay; Sivapackiam, Jothilingam; Harpstrite, Scott; Prior, Julie; Gu, Hannah; and Piwnica-Worms, David, "A Generator-Produced Gallium-68 Radiopharmaceutical for PET Imaging of Myocardial Perfusion" (2014). Chemistry & Biochemistry Faculty Works. 48.
DOI: https://doi.org/10.1371/journal.pone.0109361
Available at:
https://irl.umsl.edu/chemistry-faculty/48