Document Type
Article
Abstract
A new strategy for the activation of glycosyl halide donors to be utilized in glycosylation reactions is presented, utilizing the ferrocenium (Fc) complexes [FcB(OH)2]SbF6 and FcBF4 as promoters. The scope of the new system has been investigated using glycosyl chloride and glycosyl fluoride donors in combination with common glycosyl acceptors, such as protected glucose. The corresponding glycosylation products were formed in 95 to 10% isolated yields with α/β ratios ranging from 1/1 to β only (2 to 14 h reaction time at room temperature, 40 to 100% ferrocenium promoter load).
Publication Date
January 2021
Publication Title
RSC Advances
DOI
10.1039/D1RA05788J
Recommended Citation
Talasila, Deva and Bauer, Eike, "Ferrocenium complex aided O -glycosylation of glycosyl halides" (2021). Chemistry & Biochemistry Faculty Works. 66.
DOI: https://doi.org/10.1039/D1RA05788J
Available at:
https://irl.umsl.edu/chemistry-faculty/66