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Home > PATENTS

UMSL Patents

UMSL Patents

 
Explore a collection of patented innovations created by University of Missouri-St. Louis inventors below.
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  • Bis-amino acid based compound and use thereof by George Gokel, Joseph W. Meisel, and Mohit B. Patel

    Bis-amino acid based compound and use thereof

    George Gokel, Joseph W. Meisel, and Mohit B. Patel

    Compositions comprising bis(tryptophan) derivatives are provided that act as antimicrobials. Also provided are methods for reversing antibiotic resistance in a bacterium, or recovering or enhancing antimicrobial activity of an antibiotic against a variety of microbes, by co-administration with a bis(tryptophan) derivative.

  • Method and System for Secure Resource Management Utilizing Blockchain and Smart Contracts by Jianli Pan and Jianyu Wang

    Method and System for Secure Resource Management Utilizing Blockchain and Smart Contracts

    Jianli Pan and Jianyu Wang

    This disclosure relates to a resource management system of a computing network. The design of the resource management system is an edge-Internet of Things (IoT) framework based on blockchain and smart contracts. The resource management system integrates a permissioned blockchain to link the edge cloud resources with each account for an IoT device, resource usage, and behavior of the IoT device. The resource management system uses credit-based resource management to control the resource of the IoT device that can be obtained from the edge server. Smart contracts are used to regulate behavior of the IoT device and enforce policies.

  • Increasing the content of long chain fatty acids in seed oil by Xuemin Wang and Maoyin Li

    Increasing the content of long chain fatty acids in seed oil

    Xuemin Wang and Maoyin Li

    Provided are plants that express, or overexpress, a pPLAIIIδ protein. Constitutive or seed-specific expression of pPLAIIIδ protein in Arabidopsis increases seed oil content, the amount of C20 and C22 fatty acids, and the amount of C56, C58, and C60 triacylglycerols, effectively resulting in significantly higher oil yield per plant. Use of pPLAIIIδ is therefore an effective biotechnological tool to significantly increase plant yield, including oil, and the amount of high value long chain fatty acids in agricultural and horticultural crops, especially oilseed crops.

  • Method and system for non-invasive blood glucose measurement using signal change of the non-glucose components induced by the presence of glucose by Zhi Xu

    Method and system for non-invasive blood glucose measurement using signal change of the non-glucose components induced by the presence of glucose

    Zhi Xu

    System and methods for anonymously selecting subjects for treatment against an infectious disease caused by a pathogen. The system comprises a plurality of electronic devices comprising instructions to generate an ID and, when in proximity of another such electronic device, one or both electronic devices transmit/receive the ID to/from the other electronic device. Then, a score is generated based on a plurality of such received IDs. Additionally, based on information received from a server, relevant treatment instructions are displayed to the subjects based on the received information and the score. The server comprises instructions for sending to the plurality of electronic devices the information to be displayed with the relevant treatment instructions, additionally the server and/or the electronic devices comprise instructions to generate a prediction of likelihood of a subject transmitting the pathogen, based on the score of the subject.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor and based on the received output signal, calculating the attenuance attributable to blood in a sample with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level.

  • Enhancement of antibiotic efficacy by George Gokel, Michael Gokel, Saeedeh Negin, and Mohit Patel

    Enhancement of antibiotic efficacy

    George Gokel, Michael Gokel, Saeedeh Negin, and Mohit Patel

    Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Compositions and methods for synthetic amphiphile-induced changes in plant root morphology by George Gokel and Mohit Patel

    Compositions and methods for synthetic amphiphile-induced changes in plant root morphology

    George Gokel and Mohit Patel

    The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose by Zhi Xu

    Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose

    Zhi Xu

    A method and system for detecting glucose in a biological sample is disclosed. This includes illuminating a biological sample with a light source, collecting transmitted, transflected or reflected light from the sample with a detector, generating spectral data of one or more components in the sample other than glucose in a spectral data analysis device, and analyzing the spectral data of the one or more components, sufficient to provide a glucose measurement from the spectral data of the one or more components other than glucose with the spectral data analysis device.

  • Cyclic germanium compounds and applications thereof by Janet Braddock-Wilking, Teresa Bandrowsky, and James Carroll

    Cyclic germanium compounds and applications thereof

    Janet Braddock-Wilking, Teresa Bandrowsky, and James Carroll

    The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and for electron-transport layer components in organic light emitting diode devices.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Log complex color for visual pattern recognition of total sound by Philip Fraundorf, Stephen Wedekind, and Wayne Garver

    Log complex color for visual pattern recognition of total sound

    Philip Fraundorf, Stephen Wedekind, and Wayne Garver

    The present disclosure is generally directed to audio visualization methods for visual pattern recognition of sound. In particular, the present disclosure is directed to plotting amplitude intensity as brightness/saturation and phase-cycles as hue-variations to create visual representations of sound.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Molecules that inhibit efflux pumps in multi-drug resistant bacteria and uses thereof by George W. Gokel, Michael R. Gokel, Saeedeh Negin, and Mohit Patel

    Molecules that inhibit efflux pumps in multi-drug resistant bacteria and uses thereof

    George W. Gokel, Michael R. Gokel, Saeedeh Negin, and Mohit Patel

    Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Increasing the Content of Long Chain Fatty Acids in Seed Oil by Xuemin Wang and Maoyin Li

    Increasing the Content of Long Chain Fatty Acids in Seed Oil

    Xuemin Wang and Maoyin Li

    Provided are plants that express, or overexpress, a pPLAIIIδ protein. Constitutive or seed-specific expression of pPLAIIIδ protein in Arabidopsis increases seed oil content, the amount of C20 and C22 fatty acids, and the amount of C56, C58, and C60 triacylglycerols, effectively resulting in significantly higher oil yield per plant. Use of pPLAIIIδ is therefore an effective biotechnological tool to significantly increase plant yield, including oil, and the amount of high value long chain fatty acids in agricultural and horticultural crops, especially oilseed crops.

  • Multichannel ultra-sensitive optical spectroscopic detection by Zhi Xu

    Multichannel ultra-sensitive optical spectroscopic detection

    Zhi Xu

    Increased sensitivity of spectrometers through reducing noise in independent voltage signals via a differential voltage analyzer utilizing a reference wavelength from a wavelength region in which the optical absorption of the sample is negligible. In an embodiment, a grating permits selection of a reference wavelength. In another embodiment, filters permit selection of a reference wavelength. In yet another embodiment, both a grating and a filter permit selection of a reference wavelength. In an aspect, the differential voltage analyzer reduces noise by minimizing a differential voltage between the independent voltage signals and the reference voltage signal by adjusting the value of a cancellation coefficient.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses by James K. Bashkin, Terri Grace Edwards, Christopher Fisher, George Harris, and Kevin J. Koeller

    Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses

    James K. Bashkin, Terri Grace Edwards, Christopher Fisher, George Harris, and Kevin J. Koeller

    The present invention relates to polyamide compounds and their use in pharmaceutical compositions and in medical applications for the treatment of human papillomavirus infections and/or polyomavirus infections.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Fluorescent labeled inhibitors by Christopher D. Spilling, Benjamin Martin, Stephane Canaan, and Jean-Francois Cavalier

    Fluorescent labeled inhibitors

    Christopher D. Spilling, Benjamin Martin, Stephane Canaan, and Jean-Francois Cavalier

    Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.

    For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor and based on the received output signal, calculating the attenuance attributable to blood in a sample with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level with a sample present in target area based on the calculated attenuance with the processor.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample present in the target area.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance.

  • Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis by Zhi Xu

    Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

    Zhi Xu

    Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor and based on the received output signal, calculating the attenuance attributable to blood in a sample with a signal-to-noise ratio of at least 20-to-1; and determining a blood glucose level.

 
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