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Abstract

The invention provides a series of novel Lipid A analogs that are structually simple, synthetically accessible, and capable of blocking the cellular receptor within the signal transduction pathway. The novel Lipid A analogs can include a monosaccharide core with hydrophobic side chains and amino acid ionic motif. The invention further provides methods of using the compounds and compositions thereof in various therapeutic methods.

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Patent Number

US9120838B2

Assignee

University of Missouri System

Application Number

US14112830

Date Filed

4-18-2012

Issue Date

9-1-2015

Saccharide conjugates

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