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The invention provides a series of novel Lipid A analogs that are structually simple, synthetically accessible, and capable of blocking the cellular receptor within the signal transduction pathway. The novel Lipid A analogs can include a monosaccharide core with hydrophobic side chains and amino acid ionic motif. The invention further provides methods of using the compounds and compositions thereof in various therapeutic methods.
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University of Missouri System
Demchenko, Alexei; Nichols, Michael; and Kaeothip, Sophon, "Saccharide conjugates" (2015). UMSL Patents. 28.