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Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known μ-opioid receptor selectors as analgesics.
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The Curators of the University of Missouri, Columbia, MO
Welsh, William J.; Yu, Seong Jae; and Nair, Anil, "Opiate analogs selective for the δ-opioid receptor" (2007). UMSL Patents. 33.