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Abstract

Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known μ-opioid receptor selectors as analgesics.

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Patent Number

US7164021B2

Assignee

University of Missouri System

Application Number

US10665377

Date Filed

9-18-2003

Issue Date

1-16-2007

Opiate analogs selective for the δ-opioid receptor

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