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Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.
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The Curators of the University of Missouri, Columbia, MO
Gokel, George W.; Gokel, Michael R.; Negin, Saeedeh; and Patel, Mohit, "Molecules that inhibit efflux pumps in multi-drug resistant bacteria and uses thereof" (2019). UMSL Patents. 36.