Blood volume and hemoglobin oxygenation response following electrical stimulation of human cortex
Document Type
Article
Abstract
Our understanding of perfusion-based human brain mapping techniques relies on a detailed knowledge of the relationship between neuronal activity and cerebrovascular hemodynamics. We performed optical imaging of intrinsic signals at wavelengths sensitive to total hemoglobin (Hbt; which correlate with cerebral blood volume (CBV)) and deoxygenated hemoglobin (Hbr) directly in humans during neurosurgical operations and investigated the optical signals associated with bipolar cortical stimulation at a range of amplitudes. Cortical stimulation elicited a rapid focal increase in Hbr (initial dip) in all subjects. An equally rapid increase in Hbt (<200 ms), with a slightly higher signal-to-noise ratio, was also highly localized for <2 s in spite of the non-columnar nature of the stimulus, after which the signal spread to adjacent gyri. A later decrease in Hbr (>3 s), which is relevant to the blood oxygen level dependent (BOLD) signal, was poorly localized. Increasing the stimulus amplitude elicited a linear increase in the area of the optical signal for Hbt and the initial dip but not the late decrease in Hbr, and a nonlinear increase in optical signal amplitude with a plateau effect for initial dip, Hbt and late decrease in Hbr. © 2005 Elsevier Inc. All rights reserved.
Publication Date
5-15-2006
Publication Title
NeuroImage
ISSN
10538119
Volume
31
Issue
1
First Page
66
Last Page
75
DOI
10.1016/j.neuroimage.2005.11.030
Recommended Citation
Suh, Minah; Bahar, Sonya; Mehta, Ashesh D.; and Schwartz, Theodore H., "Blood volume and hemoglobin oxygenation response following electrical stimulation of human cortex" (2006). Physics Faculty Works. 64.
DOI: https://doi.org/10.1016/j.neuroimage.2005.11.030
Available at:
https://irl.umsl.edu/physics-faculty/64