Document Type
Article
Abstract
MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dihydroxybenzoate directly binds MarR and affects its activity.
Publication Date
September 2010
Publication Title
Journal of Bacteriology
Volume
192
Issue
18
First Page
4786
Last Page
4789
DOI
10.1128/JB.00371-10
Recommended Citation
Chubiz, Lon and Rao, Christopher, "Aromatic Acid Metabolites of Escherichia coli K-12 Can Induce the marRAB Operon" (2010). Biology Department Faculty Works. 107.
DOI: https://doi.org/10.1128/JB.00371-10
Available at:
https://irl.umsl.edu/biology-faculty/107
Included in
Biochemistry Commons, Biology Commons, Molecular Biology Commons
Comments
DOI: 10.1128/JB.00371-10