Document Type
Article
Keywords
activation, glycosylation, oligosaccharides, synthesis, transition metals
Abstract
Reported herein is a new protocol for glycosidation of alkyl and aryl thioglycosides in the presence of copper(II) bromide. While the activation with CuBr2 alone was proven suitable for reactive glycosyl donors, the activation of less reactive donors was more efficient in the presence of triflic acid as an additive. A variety of thioglycoside donors in reactions with different glycosyl acceptors were investigated to determine the initial scope of this reaction.
Publication Date
11-1-2022
Publication Title
Molecules
E-ISSN
14203049
Volume
27
Issue
21
Original Article Number
7354
Rights
CC BY
DOI
10.3390/molecules27217354
PubMed ID
36364179
Funding Number
R01GM111835
Funding Sponsor
National Institute of General Medical Sciences
Recommended Citation
Pooladian, Faranak; Escopy, Samira; and Demchenko, Alexei V., "Activation of Thioglycosides with Copper(II) Bromide" (2022). Chemistry & Biochemistry Faculty Works. 102.
DOI: https://doi.org/10.3390/molecules27217354
Available at:
https://irl.umsl.edu/chemistry-faculty/102