Document Type



Doctor of Philosophy


Chemistry, Organic

Date of Defense


Graduate Advisor

James Chickos


Bashkin, James

Stine, Keith

Harris, Wesley


Correlation gas chromatography (c-GC) is a special application of the gas chromatography technique and is used for the evaluation of both vaporization enthalpy and vapor pressures of organic compounds. Its use in measuring vaporization enthalpies has been extensively documented. This method is useful for measurements of both liquids and solids. For substances that are solids, since each analyte is dilutely adsorbed on the condensed phase of the gas chromatographic column, it is not crystalline. The vapor pressure that it exhibits behaves as an excellent model of the sub-cooled liquid as demonstrated by various thermochemical cycles. Thermochemical measurements are important to several industrial fields such as chemical and pharmaceutical manufacturing as well as to the fields of environmental and petrochemical sciences. This work focuses on the measurement of the vaporization enthalpies and vapor pressures of a series of naturally-occurring saturated and unsaturated fatty acids having a chain length between 5 and 26 carbons. Many of these materials are important commercial products and are produced in large quantities. They are often present in aerosols and are of concern as environmental pollutants. A particular fatty acid studied, valproic acid or 2-propylpentanoic acid, has been an important pharmaceutical product for many years. Its uses include the treatment of epilepsy, bipolar and other affective disorders, as well as neuropathic pain and neuralgia.

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