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Abstract
The subject invention relates to a method of synthesizing hydroxylamines from secondary amines. This method uses a dioxirane compound such as dimethyldioxirane (DMD, which is relatively stable and simple to synthesize), as the oxidizing agent. The reaction proceeds as follows: ##STR1## This method provides a simple, one-step reaction with high yields. It can be performed in acetone solution, and the transferral of an oxygen atom from dimethyldioxirane to the secondary amine converts the dioxirane into acetone, the solvent, permitting simple workup and purification. This method can be used with a wide variety of secondary amines, including aliphatic, aromatic, cyclic, and heterocyclic secondary amines, to create a corresponding variety of hydroxylamines.
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Patent Number
US5001233A
Assignee
The Curators of the University of Missouri, Columbia, MO
Application Number
407,069
Date Filed
9-14-1989
Issue Date
3-19-1991
Recommended Citation
Murray, Robert W. and Singh, Megh, "Synthesis of Hydroxylaminesusing Doxiranes" (1991). UMSL Patents. 27.
https://irl.umsl.edu/patents/27
Comments
5001233