Chen Keasar, Ben-Gurion University of the Negev
Liam McGuffin, University of Reading
Björn Wallner, Linköping University
Gaurav Chopra
Badri Adhikari, University of Missouri
Debswapna Bhattacharya, Auburn University
Lauren Blake, Lawrence Berkeley National Laboratory
Leandro Bortot, University of São Paulo
Renzhi Cao, University of Missouri
B. Dhanasekaran, Indian Institute of Science
Itzhel Dimas, Lawrence Berkeley National Laboratory
Rodrigo Faccioli, University of São Paulo
Eshel Faraggi, The Research Institute at Nationwide Children's Hospital
Robert Ganzynkowicz, University of Gdańsk
Sambit Ghosh, Indian Institute of Science
Soma Ghosh, Indian Institute of Science
Artur Giełdoń, University of Gdańsk
Lukasz Golon, University of Gdańsk
Yi He, University of California, Merced
Lim Heo, Seoul National University
Jie Hou, University of Missouri
Main Khan, University of Massachusetts Dartmouth
Firas Khatib, University of Massachusetts Dartmouth
George Khoury, Princeton University
Chris Kieslich, Texas A&M University
David Kim, University of Washington
Pawel Krupa, University of Gdańsk
Gyu Lee, Seoul National University
Hongbo Li, Northeast Normal University
Jilong Li, University of Missouri
Agnieszka Lipska, University of Gdańsk
Adam Liwo, University of Gdańsk
Ali Maghrabi, University of Reading
Milot Mirdita, Max Planck Society
Shokoufeh Mirzaei, California State Polytechnic University, Pomona
Magdalena Mozolewska, University of Gdańsk
Melis Onel, Texas A&M University
Sergey Ovchinnikov, University of Washington
Anand Shah, University of Massachusetts Dartmouth
Utkarsh Shah, Texas A&M University
Tomer Sidi, Ben-Gurion University of the Negev
Adam Sieradzan, University of Gdańsk
Magdalena Ślusarz, University of Gdańsk
Rafal Ślusarz, University of Gdańsk
James Smadbeck, Princeton University
Phanourios Tamamis, Texas A&M University
Nicholas Trieber, University of Massachusetts Dartmouth
Tomasz Wirecki, University of Gdańsk
Yanping Yin, Cornell University

Document Type

Article

Abstract

Every two years groups worldwide participate in the Critical Assessment of Protein Structure Prediction (CASP) experiment to blindly test the strengths and weaknesses of their computational methods. CASP has signifcantly advanced the feld but many hurdles still remain, which may require new ideas and collaborations. In 2012 a web-based efort called WeFold, was initiated to promote collaboration within the CASP community and attract researchers from other felds to contribute new ideas to CASP. Members of the WeFold coopetition (cooperation and competition) participated in CASP as individual teams, but also shared components of their methods to create hybrid pipelines and actively contributed to this efort. We assert that the scale and diversity of integrative prediction pipelines could not have been achieved by any individual lab or even by any collaboration among a few partners. The models contributed by the participating groups and generated by the pipelines are publicly available at the WeFold website providing a wealth of data that remains to be tapped. Here, we analyze the results of the 2014 and 2016 pipelines showing improvements according to the CASP assessment as well as areas that require further adjustments and research.

Publication Date

12-1-2018

Publication Title

Scientific Reports

Volume

8

Issue

1

First Page

9939

DOI

10.1038/s41598-018-26812-8

Comments

Published by 'BMC Bioinformatics' at 10.1186/s12859-015-0775-x.

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